Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system characterized by inflammation, demyelination and neurodegeneration. Natalizumab is a widely used anti-α4 integrin inhibitor for treating highly active MS. In the pivotal trials of natalizumab for MS, the SENTINEL and AFFIRM trials, natalizumab was established to reduce the rate of clinical relapses and […]

Dravet syndrome is a rare genetic disorder that affects approximately 1 in 15,700 individuals. It is one of the most severe epilepsy syndromes of early childhood, with high morbidity and mortality rates.1,2 It is characterized by seizures that begin in infancy and can lead to intellectual disability, developmental delays and a range of other neurological problems.3 The SCN1A gene […]

In modern medicine, the concept of wellness is accompanied by many misconceptions. Adopting wellness as a treatment approach has been well defined and implemented in cardiovascular disease, diabetes and some types of cancer management but has not yet been widely applied to neurologic diseases.1–5 The commercialization of the wellness industry has led to the misconception of wellness as expensive and only accessible to a niche population […]

Welcome to the latest edition of touchREVIEWS in Neurology, featuring a range of interviews, reviews and reports on some of the key recent developments in neurological disease. We open with three expert interviews with key members of the pan-European organisation, Alzheimer Europe on the topic of care for people with dementia. In the first, Owen […]

Highlights Limb–joint contractures may represent an important clinical clue of muscle dystrophies, as they limit the spectrum of the diagnosis assumptions. Limb–girdle muscular dystrophies phenotype can rarely be a clinical presentation of retractile myopathies, except for non-specific Achilles tendon tightness. Anti-PM/Scl antibody screening using line-blot assays and commercial antibody–panel testing is likely to detect false-positive antibodies. Dysferlinopathies, calpainopathy and facioscapulohumeral muscular dystrophy are the conditions most frequently confused […]

In an expert interview, Owen Miller, Policy Officer at Alzheimer Europe, Luxembourg, discusses the Dementia in Europe Yearbook 2022: Employment and Related Social Protection for People with Dementia and their Carers (henceforth, the Yearbook).1 The Yearbook is a report that provides an overview of the challenges and opportunities that people with dementia and their caregivers face in Europe. It is published by […]

The novel severe acute respiratory syndrome coronavirus 2 has caused a worldwide pandemic, and its impact on healthcare systems around the world is still being investigated. The potential effect of coronavirus disease 2019 (COVID-19) on people living with dementia and the ability of COVID-19 to precipitate the risk of developing dementia are particular areas of concern. This article provides an overview of the current understanding of the impact […]

The report entitled “Sex, gender and sexuality in the context of dementia: A guide to raise awareness amongst health and social care workers“ is a guide published by Alzheimer Europe that offers practical advice to health and social care workers on how to address issues related to sex, gender and sexuality in the context of dementia.1 The guide […]

The Guidelines for the ethical and inclusive communication about portrayal of dementia and people with dementia were published by Alzheimer Europe and the European Working Group of People with Dementia (EWGPWD).1,2 The document provides guidance on how to communicate about dementia and people living with dementia ethically and inclusively. The guidelines emphasize the importance of respecting the rights and dignity of individuals with dementia and of avoiding stigmatizing […]