US Neurology – SUPPLEMENT 1 – 2018

Stuart H Isaacson, Daniel E Kremens

 Pathologically, Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies.1 In a staging model proposed by Braak in 2003,2 the presence of midbrain lesions are preceded by degeneration and Lewy bodies in lower brain stem nuclei. Indeed, non-motor features such as constipation, […]